Chronic & Neurological Diseases

Introduction

Neurobiology is a multidisciplinary science that involves study of structure and function of the nervous system for understanding the behavioral, cognitive and development aspects of the nervous system at the cellular and molecular level. The major thrust area under the neurobiology program is to support the R&D activities for understanding the

  1. Brain function and its disorders or pathogenesis at the cellular & molecular level,
  2. Development of neurological tools & techniques
  3. Supporting cohort studies for major neurological disorders / pathological conditions 
  4. Building platforms for advancing the technological competency for brain functions and disorders

Major Programs and initiatives

  • Dementia Science ProgramThe general objectives of the project include setting up of three long-term population-based cohorts of aging population to understand the process of Dementia in terms of its incidence and prevalence rate. Four hospital based registries will be established to catch the clinically defined Dementia population along with setting up of a Bio-bank/Bio-repository at NBRC, Manesar.

assessment

Neuro cognitive assessment

  • Centre of Excellence in the area of Neuro-engineering for Excellence in Innovation and Translational Research Development.

3d tracking

3D Tracking and Navigation Simulator for Neuro-Endoscopy

  • A Population Based Prospective Cohort Study to Unravel the Causes of Stroke and Cognitive Decline: Under the project incidence and risk / protection factors for stroke and cognitive decline will be determined in an urban and rural community
  • Hypoxia Ischemic Brain Injury (HIBI): Study of hypoxia on different neural cell type; creation of in vitro model to design therapeutic strategies against cerebral palsy in preterm infants, hypoxia induced changes in Blood Brain Barrier and adjunct therapeutic interventions will be studied.

immuno

Immuno fluorescence image of FNSCs stained for neural stem cell markers Nestin (red) and Sox2 (green). Nuclei are stained with DAPI (blue)

  • Glial Cell Biology: Projects shave been implemented to explore issues pertaining to neuro-inflammation, glial activation in hypertension, neurodegeneration and neuronal cell death.

New Initiatives

A Call for proposal for developing neurotools, techniques, and procedures for brain disorders and pathological conditions was made in the year 2021-22. The major goal is to start the novel & innovative biotechnology based ideas in the domain of neurobiology for making available affordable technology for diagnostic & therapeutic purpose for routine examination by the clinicians or for the direct utilization by the patients.

Publications

2022

  1. Desai, S. S., Whadgar, S., Raghavan, S. C., Choudhary, B. (2022). MiRAGDB: A Knowledgebase of RAG Regulators. Front. Immunol. 13:863110. doi: 10.3389/fimmu.2022.863110
  2. Dhanya, Sreeja Kumari and Hasan, G. (2022). Two photon imaging of calcium responses in murine Purkinje neurons. Star Protocols 3, 101105. https://doi.org/10.1016/j.xpro.2021.101105
  3. Dubey, V., Dey, S., Dixit, A. B., Tripathi, M., Chandra, P. S., & Banerjee, J. (2022). Differential glutamate receptor expression and function in the hippocampus, anterior temporal lobe and neocortex in a pilocarpine model of temporal lobe epilepsy. Experimental neurology, 347, 113916.
  4. Mitra, R and Hasan, G (2022). Store-operated Ca2+entry regulates neuronal gene expression and function. Current Opinion in Neurobiology, 73:102520.
  5. Mondal P, Tiwary N, Sengupta A, Dhang S, Roy S and Das C. (2022). Epigenetic reprogramming of the Glucose metabolic pathways by the Chromatin effectors during Cancer. Subcellular Biochemistry. In Metabolism and Epigenetic Regulation: Implications in Cancer. Publisher: Springer Nature (In Press)
  6. Pandita T.K., Hunt C.R, Singh V, Adhikary S, Pandita S, Roy S, Ramos K, and Das C. (2022). Role of the histone acetyl transferase MOF and the histone deacetylase Sirtuins in regulation of H4K16ac during DNA damage repair and metabolic programming: Implications in Cancer and Aging. Subcellular Biochemistry. In Metabolism and Epigenetic Regulation: Implications in Cancer. Publisher: Springer Nature (In Press)
  7. Prasad K, Dwivedi SN, Kant S, Vibha D, Pandit AK, Karthikeyan G, Tripathi M, Srivastava AK, Nehra A, Vivekanandhan S, Garg A, Chutani AM, Verma V, Kumar S, Kumar A, Gulati K, Gulati A, Makharia G, Seth T, Dhingra K, Mandal PK, Mishra NK, Ikram A, Tiemeier H (2022). Cohort Profile: The LoCARPoN-a population-based prospective cohort study in middle-aged and older adults in India. Int J Epidemiol. 18; 51(1): 29-30
  8. R. Singh, A. Suri, “An Ergonomic Neuro-endoscopic Instrument Handle Design using 3D Printing.” Neurology India. 2022.
  9. Shrivastava V, Dey D, Singal CMS, Jaiswal P, Singh A, Sharma JB, Chattopadhyay P, Nayak NR, Palanichamy JK, Sinha S, Seth P, Sen S.  Glutamate uptake is not impaired by hypoxia in a culture model of human fetal neural stem cell-derived astrocytes.Genes, 2022; 13(3): 506. doi.org/10.3390/genes13030506

2021

  1. Adhikary S, Roy S, Chacon J, Gadad S.S. and Das C. (2021). Implications of enhancer transcription and eRNAs in cancer. Cancer Res. 81(16):4174-4182.
  2. Amalakanti S, Bhat UA, Madhavi MB, Khandelwal N, Sundarachary NV, Chakravarty S, Kumar A (2021). Gene Expression analysis identifies cholesterol metabolism dysregulation in hippocampus of phenytoin resistant pentylenetetrazol kindled epileptic mice. Neuromolecular Medicine Feb 18, doi: 10.1007/s12017-021-08648-0.
  3. Bhat SA, Fatima Z, Sood A, Shukla R, Hanif K. (2021). The Protective effects of AT2R Agonist, CGP42112A, against angiotensin II-induced oxidative stress and inflammatory response in astrocytes: Role of AT2R/PP2A/NFκB/ROS Signaling. Neurotox
  4. Desai, S. S., Rao, K. R., Jain, A., Bawa, P. S., Dutta, P., Atre, G., Subhash, A., Rao, V., J, S., Srinivasan, S., & Choudhary, B. (2021). Multidimensional Mutational Profiling of the Indian HNSCC Sub-Population Provides IRAK1, a Novel Driver Gene and Potential Druggable Target. Frontiers in Oncology, 11. doi: Artn 72316210.3389/Fonc.2021.723162
  5. Dhanya, Sreeja Kumari and Hasan, G. (2021). Deficits associated with loss of STIM1 in Purkinje neurons, including motor deficits can be rescued by loss of Septin 7. Front. Cell Dev. Biol. 9:794807. doi: 10.3389/fcell.2021.794807
  6. Dhanya, Sreeja Kumari and Hasan, G., (2021). Purkinje neurons with loss of STIM1 exhibit age-dependent changes in gene expression and synaptic components. J. Neurosci41, 3777-3798. https://doi.org/10.1523/JNEUROSCI.2401-20.2021.
  7. Dubey, V., Dey, S., Tripathi, M., Chandra, S., Banerjee, J., & Dixit, A. (2021). Expression of Glutamate receptor subunits in the hippocampus, anterior temporal lobe and neocortex of pilocarpine model of temporal lobe epilepsy. Epilepsia, 62, 99.
  8. Halder, A., Singh, R., Suri, A., & Joshi, D. (2021). Predicting State Transition in Freezing of Gait via Acceleration Measurements for Controlled Cueing in Parkinson’s Disease. IEEE Transactions on Instrumentation and Measurement, 70, 1-16.
  9. Haq SU, Bhat UA, Kumar A (2021) Prenatal stress effects on offspring brain and behavior: Mediators, alterations and dysregulated epigenetic mechanisms. J Bioscience 46:34.
  10. HarshaRani GV, Moza S, Ramakrishnan N, Bhalla US.  (2021). SWITCHES: Searchable web interface for topologies of CHEmical switches. Bioinformatics.  doi: 10.1093/bioinformatics/btab006.
  11. Iyer H, Wahul AB, P K A, Sawant BS, Kumar A (2021). A BRD's (BiRD's) eye view of BET and BRPF bromodomains in neurological diseases. Rev Neuroscience 32(4):403-426.
  12. Joshi, R., Sipani, R., & Bakshi, A. (2021). Roles of Drosophila Hox Genes in the Assembly of Neuromuscular Networks and Behavior. Front Cell Dev Biol, 9, 786993. doi: 10.3389/fcell.2021.786993
  13. Kumar, S., Olson, A.C., Koelle, M.R. (2021). The neural G protein Gαo tagged with GFP at an internal loop is functional in Caenorhabditis elegans. G3 (Bethesda), 11(8).
  14. Kumari, R., Roy, U., Desai, S., Nilavar, N. M., Van Nieuwenhuijze, A., Paranjape, A., Radha, G., Bawa, P., Srivastava, M., Nambiar, M., Balaji, K. N., Liston, A., Choudhary, B., & Raghavan, S. C. (2021). MicroRNA miR-29c regulates RAG1 expression and modulates V(D)J recombination during B cell development. Cell Reports, 36(2). doi: Artn 10939010.1016/J.Celrep.2021.109390
  15. Mitra R, Richhariya S, Jayakumar S, Notani D, Hasan G. (2021). IP3-mediated Ca2+ signals regulate larval to pupal transition under nutrient stress through the H3K36 methyltransferase Set2. Development.148:dev199018; doi: 10.1242/dev.199018
  16. Nilavar, N. M., & Raghavan, S. C. (2021). HIV integrase inhibitors that inhibit strand transfer interact with RAG1 and hamper its activities. International Immunopharmacology, 95. doi: Artn 10751510.1016/J.Intimp.2021.107515
  17. Pandey N, Rastogi M, Singh S.K., (2021) Chandipura virus dysregulates the expression of hsa-miR-21-5p to activate NF-κB in human microglial cells. J Biomed Sci. 2021 Jul 7;28(1):52. doi: 10.1186/s12929-021-00748-0 Psyhiatry, 11 (494).
  18. Roy, U., & Raghavan, S. C. (2021). Deleterious point mutations in T-cell acute lymphoblastic leukemia: Mechanistic insights into leukemogenesis. International Journal of Cancer, 149(6), 1210-1220. doi: 10.1002/ijc.33527
  19. Sharma, R., & Suri, A. (2021). Microsurgical suturing assessment scores: a systematic review. Neurosurgical Review, 1-6.
  20. Singh, R., Baby, B., Singh, R., & Suri, A. (2021). Role of virtual modules to supplement neurosurgery education during COVID-19. Journal of Clinical Neuroscience, 91, 125-130.
  21. Sumana Chakravarty, Unis Ahmad Bhat, R. Gajendra Reddy, Praveer Gupta, Arvind Kumar (2021). Histone Deacetylase Inhibitors and Psychiatric Disorders (Chapter 28) In: Epigenetics in Psychiatry, Eds. Jacob Peedicayil, Dennis R. Grayson, Dimitrios Avramopoulos, pp. 657-699, Elsevier Academic Press.
  22. T. Joshi, V. Kumar, E. V. Kaznacheyevaand  N.R. Jana (2021). WithaferinA Induces Heat Shock Response and Ameliorates Disease Progression in a Mouse Model of Huntington’s Disease. Molecular Neurobiology, 58, 3992-4006.

2020

  1. Baby, B., Singh, R., Singh, R., & Suri, A. (2020). In Reply to the Letter to the Editor Regarding" A Review of Physical Simulators for Neuroendoscopy Skills Training". World Neurosurgery, 141, 531-532.
  2. Baby, B., Singh, R., Singh, R., Suri, A., Arora, C., Kumar, S., ... & Banerjee, S. (2020). A review of physical simulators for neuroendoscopy skills training. World Neurosurgery, 137, 398-407.
  3. Baby, B., Singh, R., Suri, A., Dhanakshirur, R. R., Chakraborty, A., Kumar, S., ... & Banerjee, S. (2020). A review of virtual reality simulators for neuroendoscopy. Neurosurgical Review, 43(5), 1255-1272.
  4. Bakshi, A., & Joshi, R. (2020). Role of glial niche in regulating neural stem cell proliferation in Drosophila central nervous system. J Neurosci Res, 98(12), 2373-2375. doi: 10.1002/jnr.24713
  5. Bakshi, A., Sipani, R., Ghosh, N., & Joshi, R. (2020). Sequential activation of Notch and Grainyhead gives apoptotic competence to Abdominal-B expressing larval neuroblasts in Drosophila Central nervous system. PLoS Genet, 16(8), e1008976. doi: 10.1371/journal.pgen.1008976
  6. Deb, B.K., Chakraborty, P., Gopurapilly, R and Hasan, G (2020). SEPT7 regulates Ca2+ entry through Orai channels in human neural progenitor cells and neurons. Cell Calcium 90, 102252. https://doi.org/10.1016/j.ceca.2020.102252
  7. Dey D, Shrivastava V, Bhat MA, Singal CMS, Jaiswal P, Sharma JB, Chattopadhyay P, Sinha S, Seth P, Sen S. Evaluating the effect of hypoxia on human fetal neural stem cells in vitro.Proceedings of annual meeting of international society for stem cell research (2020 Virtual, 23 – 27 June 2020). CI250: Page 158-9.
  8. HarshaRani GV, Moza S, Ramakrishnan N, Bhalla US.  (2021). SWITCHES: Searchable web interface for topologies of CHEmical switches. Bioinformatics.  doi: 10.1093/bioinformatics/btab006.
  9. Hasan, G and Sharma, A (2020). Regulation of neuronal physiology by Ca2+ release through the IP3R. Curr Op in Phys 17, 1-8. Invited review.
  10. Mukherjee S, Adhikary S, Gadad S.S., Mondal P, Sen S., Choudhari R., Singh V., Adhikari S., Mandal P., Chaudhuri S., Sengupta A., Lakshmanaswamy R., Chakrabarti P, Roy S and Das C. (2020). Suppression of poised oncogenes by ZMYND8 promotes chemo-sensitization. Cell Death Dis. 11(12):1073.
  11. Nilavar, N. M., Nishana, M., Paranjape, A. M., Mahadeva, R., Kumari, R., Choudhary, B., & Raghavan, S. C. (2020). Znc2 module of RAG1 contributes towards structure-specific nuclease activity of RAGs. Biochemical Journal, 477(18), 3567-3582. doi: 10.1042/Bcj20200361
  12. Nilavar, N. M., Paranjape, A. M., & Raghavan, S. C. (2020). Biochemical activity of RAGs is impeded by Dolutegravir, an HIV integrase inhibitor. Cell Death Discovery, 6(1). doi: ARTN 5010.1038/s41420-020-0281-4
  13. Ray, U., Raul, S. K., Gopinatha, V. K., Ghosh, D., Rangappa, K. S., Mantelingu, K., & Raghavan, S. C. (2020). Identification and characterization of novel SCR7-based small-molecule inhibitor of DNA end-joining, SCR130 and its relevance in cancer therapeutics. Molecular Carcinogenesis, 59(6), 618-628. doi: 10.1002/mc.23186
  14. Reddy RG, Bhat UA, Chakravarty S, Kumar A (2020) Advances in histone deacetylase inhibitors in targeting glioblastoma stem cells. Cancer Chemotherapy Pharmacology 86(2):165-179.
  15. Sen S, Shrivastava V, Dey D, Singh A, Singal CMS, Jaiswal P, Sharma JB, Chattopadhyay P, Kumar J, Sinha S, Seth P.Assessing glutamate uptake after hypoxic injury in astrocytes derived from human fetal neural stem cells in vitro.Proceedings of annual meeting of international society for stem cell research (2020 Virtual, 23 – 27 June 2020). MDD276: Page 188.
  16. Sharma, Anamika and Hasan, G., (2020). Modulation of flight and feeding behaviours requires presynaptic IP3Rs in dopaminergic neurons.eLife9:e62297. DOI: https://doi.org/10.7554/eLife.62297
  17. Singh, R., & Suri, A. (2020). Three-Dimensional Printed Ergonomically Improved Microforceps for Microneurosurgery. World Neurosurgery, 141, e271-e277.

2019

  1. Annapoorna PK, Iyer H, Parnaik T, Narasimhan H, Bhattacharya A, Kumar A (2019) FTO: An Emerging Molecular Player in Neuropsychiatric Diseases. Neuroscience, 418:15-24.
  2. Bhat SA, Sood A, Shukla R, Hanif K. (2019). AT2R Activation prevents microglia pro-inflammatory activation in a NOX-dependent manner: Inhibition of PKC activation and p47phox phosphorylation by PP2A. Mol Neurobiol. 56(4):3005-3023
  3. Dwivedi, D., Chattarji S., & Bhalla, U.S. (2019) Impaired Reliability and Precision of Spiking in Adults But Not Juveniles in a Mouse Model of Fragile X Syndrome. eNeuro 6(6) ENEURO.0217-19.2019 1–24
  4. Ghosh, N., Bakshi, A., Khandelwal, R., Rajan, S. G., & Joshi, R. (2019). The Hox gene Abdominal-B uses Doublesex(F) as a cofactor to promote neuroblast apoptosis in the Drosophila central nervous system. Development, 146(16). doi: 10.1242/dev.175158
  5. Gopurappilly R., Deb B.K., Chakraborty P., Hasan G. (2019) Measurement of Store-Operated Calcium Entry in Human Neural Cells: From Precursors to Differentiated Neurons. In: Joglekar M., Hardikar A. (eds) Progenitor Cells. Methods in Molecular Biology, vol 2029. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9631-5_20.
  6. Khandelwal N, Dey S, Chakravarty S, Kumar A (2019). MiR-30 family miRNAs mediate the effect of chronic social defeat stress on hippocampal neurogenesis in mouse depression model. Frontiers in Molecular Neuroscience, 12, 188
  7. Kumari, N., Vartak, S. V., Dahal, S., Kumari, S., Desai, S. S., Gopalakrishnan, V., Choudhary, B., & Raghavan, S. C. (2019). G-quadruplex Structures Contribute to Differential Radiosensitivity of the Human Genome. IScience, 21, 288-+. doi: 10.1016/j.isci.2019.10.033
  8. Manjila, S. B., Kuruvilla, M., Ferveur, J-F., Sane, S. P. and Hasan, G. (2019). Extended flight bouts require disinhibition from GABAergic Mushroom Body neurons. Current Biology, 29, 283-293. https://doi.org/10.1016/j.cub.2018.11.070
  9. Megha, Wegener, C. and Hasan, G. (2019). ER-Ca2+ sensor STIM regulates neuropeptides required for development under nutrient restriction in Drosophila.  PlosOne, https://doi.org/10.1371/journal.pone.0219719
  10. N. Vatsa, V. Kumar, B.K. Singh, S. S. Kumar, A. Sharma and N.R. Jana(2019). Down-regulation of miRNA-708 promotes aberrant calcium signaling by targeting neuronatin in a mouse model of Angelman syndrome.  Frontiers in Molecular Neuroscience, 12, 35, 2019.
  11. Singh, R., Baby, B., & Suri, A. (2019). A virtual repository of neurosurgical instrumentation for neuroengineering research and collaboration. World Neurosurgery, 126, e84-e93
  12. V. Kumar, T. Joshi, N Vatsa, B.K. Singh, N.R. Jana(2019).Simvastatin Restores HDAC1/2 Activity and Improves Behavioral Deficits in Angelman Syndrome Model Mouse. Frontiers in Molecular Neuroscience 12, 289, 2019.
  13. Yadav S, Surolia A., Lysozyme elicits pain during nerve injury by neuronal Toll-like receptor 4 activation and has therapeutic potential in neuropathic pain., Sci Transl Med. 2019 11(504).

2018

  1. B.K. Singh, N. Vatsa, V.K. Nelson, V. Kumar, S.S. Kumar, S.C. Mandal, M. Pal and N. R. Jana(2018). Azadiradione Restores Protein Quality Control and Ameliorates the Disease Pathogenesis in a Mouse Model of Huntington’s Disease. Molecular Neurobiology, 55, 6337-6346.
  2. Bakshi, A., & Joshi, R. (2018). Understanding the regulation of neural stem cell proliferation in Drosophila central nervous system. J Neurosci Res, 96(6), 1119-1120. doi: 10.1002/jnr.24234
  3. Bhagat, R., Prajapati, B., Narwal, S., Agnihotri, N., Adlakha, Y.K., Sen, J., Mani, S. and Seth, P. (2018). Zika virus E protein alters the properties of human fetal neural stem cells by modulating microRNa circuitry. Cell Death and Differentiation, (10) 1837-1854.
  4. Bhat SA, Goel R, Shukla S, Shukla R, Hanif K. (2018). Angiotensin receptor blockade by inhibiting glial activation promotes hippocampal neurogenesis via activation of Wnt/β-catenin signaling in hypertension. Mol Neurobiol. 55(6):5282-5298. 
  5. Deb, B. K and Hasan, G. (2018). Sept7-mediated regulation of Ca2+ entry through Orai channels requires other Septin subunits. Cytoskeleton 2018;1-11. doi.org/10.1002/cm.21476
  6. Evaluating the effect of hypoxia on human fetal neural stem cells in vitro. Dey D, Shrivastava V, Singal C, Mehta A, Bhat MA, Sharma JB, Palanichamy JK, Chattopadhyay P, Sinha S, Seth P, Sen S.Ind J Clin Biochem, 2018; 33(Suppl 1): p45
  7. Gopurapilly, R., Deb, B.K., Chakraborty, P. and Hasan, G.(2018) Stable STIM1 knockdown in self-renewing humanneural precursors promotes premature neural differentiation. Front. Mol. Neurosci,11:178, doi: 10.3389/fnmol.2018.00178
  8. Jayakumar, S and Hasan, G (2018). Neuronal calcium signaling in metabolic regulation and adaptation to nutrient stress. Front. Neural Circuits | doi: 10.3389/fncir.2018.00025
  9. Jayakumar, S., Richhariya, S., Deb, B. K. and Hasan, G. (2018). A multi-component neuronal response encodes the larval decision to pupariate upon amino acid starvation. J. Neuroscience, 38, 10202-10219. DOI: https://doi.org/10.1523/JNEUROSCI.1163-18.2018
  10. Mishra PK, Kumar A, Behar KL, Patel AB (2018) Subanesthetic ketamine reverses neuronal and             astroglial metabolic activity deficits in a social defeat model of depression. J Neurochemistry, 146(6), 722.
  11. N. Vatsa and N.R. Jana (2018). UBE3A and its link with autism. Frontiers in Molecular Neuroscience, 11, 448.
  12. Ravi, P., Trivedi, D. and Hasan, G. (2018). FMRFa receptor stimulated Ca2+ signals alter the activity of flight modulating central dopaminergic neurons in Drosophila melanogaster. Plos Genetics, doi: 10.1371/journal.pgen.1007459.
  13. Richhariya, S., Jayakumar, S., Sukumar, S. K. and Hasan, G (2018). dSTIM and Ral/exocyst mediated synaptic release from pupal dopaminergic neurons sustains Drosophila flight. eNeuro5(3) e0455-17.2018, 1–12,DOI: 10.1523/ENEURO.0455-17.2018
  14. Saxena, M., Agnihotri, N. and Sen, J. (2018). Perturbation of canonical and non-canonical BMP signaling affects migration, polarity and dendritogenesis of mouse cortical neurons. Development, 145 (1) 147-157.
  15. Thillaiappan, N.B., Chakraborty, P., Hasan, G and Taylor, C.W. (2018).  IP3 receptors and Ca2+ entry. BBA - Mol Cell Res. doi: 10.1016/j.bbamcr.2018.11.007. Invited review
  16. Viswan NA, HarshaRani GV, Stefan MI, Bhalla US. (2018). FindSim: A Framework for Integrating Neuronal Data and Signaling Models. Front Neuroinform. 2:38. doi: 10.3389/fninf.2018.00038.

2017

  1. B.K. Singh, N. Vatsa, V. Kumar, S. Shekhar, A. Sharma and N.R. Jana(2017). Ube3a deficiency inhibits amyloid plaque formation in APPswe/PS1δE9 mouse model of Alzheimer’s disease. Human Molecular Genetics, 26(20), 4042-4054.
  2. Bhat SA, Goel R, Shukla R, Hanif K. (2017). Platelet CD40L induces activation of astrocytes and microglia in hypertension. Brain Behav Immun. 59:173-189.
  3. Chakraborty, S and Hasan, G (2017), Spontaneous Ca2+ Influx in Drosophila Pupal Neurons Is Modulated by IP3-Receptor Function and Influences Maturation of the Flight Circuit. Frontiers in Molecular Neuroscience, 10, doi:10.3389/fnmol.2017.00111
  4. Chakravarty S, Jhelum P, Bhat UA, Rajan WD, Maitra S, Pathak SS, Patel AB, Kumar A (2017). Insights into the epigenetic mechanisms involving histone lysine methylation and demethylation in ischemia induced damage and repair has therapeutic implication. Biochimica et Biophysica Acta, 1863:152–164.
  5. Jamal,  V. Kumar, N. Vatsa, B.K. Singh, S. Shekhar, A. Sharma and N.R. Jana (2017). Environmental enrichment improves behavioural abnormalities in a mouse model of Angelmansymdrome. Molecular Neurobiology, 54, 5319-5326.
  6. Jamal,  V. Kumar, N. Vatsa, S. Shekhar, B.K. Singh, A. Sharma and N.R. Jana(2017). Rescue of altered HDAC activity recovers behavioural abnormalities in a mouse model of Angelman syndrome. Neurobiology of Diseases, 105, 99-108.
  7. K. Debnath, N Pradhan, B.K. Singh, Nihar R. Jana and Nikhil R. Jana(2017). Poly(trehalose) Nanoparticles prevent amyloid aggregation and suppress polyglutamine aggregation in a Huntington's disease model mouse. ACS Applied Materials & Interfaces,9, 24126-24139.
  8. Khandelwal, R., Sipani, R., Govinda Rajan, S., Kumar, R., & Joshi, R. (2017). Combinatorial action of Grainyhead, Extradenticle and Notch in regulating Hox mediated apoptosis in Drosophila larval CNS. PLoS Genet, 13(10), e1007043. doi: 10.1371/journal.pgen.1007043
  9. Kukreja, S., Gautam, P., Saxena, R., Saxena, M., Udaykumar, N., Kumar, A., Bhatt, R., Kumar, V. and Sen, J. (2017). Identification of novel candidate regulators of retinotectal map formation through transcriptional profiling of the chick optic tectum. J Comp Neurol., 525(3):459-477.
  10. Megha and Hasan, G (2017). Control of protein translation by IP3R-mediated Ca2+ release in Drosophila neuroendocrine cells. Fly,11, 290-296. DOI: 10.1080/19336934.2017.1384103
  11. Megha and Hasan, G. (2017), IP3R-mediated Ca2+ release regulates protein metabolism in Drosophila neuroendocrine cells: implications for development under nutrient stress. Development, 144, 1484-1489 doi:10.1242/dev.145235
  12. N.Pradhan, S.Shekhar, Nihar R. Jana and Nikhil R. Jana (2017). Sugar-terminated nanoparticle chaperones are 102–105 times better than molecular sugars in inhibiting protein aggregation and reducing amyloidogenic cytotoxicity. ACS Applied Materials & Interfaces, 9, 10554-10566.
  13. Pathak SS, Maitra S, Chakravarty S, Kumar A (2017). Histone lysine demethylases of JMJD2 or KDM4 family are important epigenetic regulators in reward circuitry in the etiopathology of depression. Neuropsychopharmacology, 42(4):854-863.
  14. Pathak, T., Trivedi, D. and Hasan, G. (2017), CRISPR-Cas induced mutants identify a requirement for dSTIM in larval dopaminergic cells of Drosophila melanogaster G3: Genes, genomics, genetics 7, 923-933. https://doi.org/10.1534/g3.116.038539
  15. Richhariya, S., Jayakumar S., Abruzzi, K., Rosbash, M.R. and Hasan G. (2017), A pupal transcriptomic screen identifies Ral as a target of store-operated calcium entry in Drosophila neurons. Scientific Reports7:42586 | DOI: 10.1038/srep42586.
  16. S. Shekhar, N. Vatsa, V. Kumar, B.K. Singh, I Jamal, A. Sharma and N.R. Jana(2017). Topoisomerase inhibitor topotecan delays the disease progression in a mouse model of Huntington’s disease.  Human Molecular Genetics, 26, 420-429.

List of Patents applied

  1. Ramandeep Singh, Rajdeep Singh, Ashish Suri. “Endoscopic Endonasal Transsphenoidal Surgery Trainer with Integrated Sensor based Evaluation of Surgical Skills” (Indian Patent Application No.: 202211012682 dated 09-03-2022).

Endoscopic

  1. Britty Baby, Ashish Suri, Chetan Arora, Subhashis Banerjee, Prem Kumar Kalra, Subodh Kumar, Ramandeep Singh, “3D Tracking and Navigation Simulator for Neuro-Endoscopy” (Indian Patent Application No.: 202211012683 dated 09-03-2022).
  1. Ramandeep Singh, Rajdeep Singh, Ashish Suri. Invention entitled, “Surgeon Specific Three-Dimensional Printed Protective Eye Gear with Prescription Glasses” (Application submitted to the DBT Patent Cell).

surgeon

Contacts Concerned Officer for more Information

Programme Head Dr. Anamika Gambhir, Scientist G
Email anamika[at]dbt[dot]nic[dot]in
Phone No. 011-24363665
Programme Officer Email Phone No.
Dr. Neha Bansal, Scientist D neha[dot]bansal[at]dbt[dot]nic[dot]in